Endocrine Abstracts

Background: Over the last two decades, type 2 diabetes mellitus (T2DM) has increasingly been recognized as a fracture risk factor, despite the occurrence of normal to even increased bone mineral density (BMD) (1). The dual energy X-ray absorptiometry (DXA) derived trabecular bone score (TBS) is considered to be a proxy of bone quality and has been reported to be diminished in diabetic patients (2) and insulin resistant, non-diabetic postmenopausal women (3).</...

Background: Bone turnover markers are used in research and clinical practice, but only in part reflect bone formation and resorption. Components of the Wnt-signaling pathway, regulating osteoblastogenesis and osteoblast function, can be measured in serum, however it is unclear whether they reflect underlying bone mass and metabolism.Objective: Determine whether serum levels of Wnt-signalling components reflect bone mass or metabolism in men during growth...

Background: Impaired bone geometry and/or aberrant bone matrix formation may underlie the increased fracture risk observed in patients with type 1 diabetes mellitus (T1DM). Although reduced areal and volumetric bone mineral density (aBMD, vBMD) have been observed in pediatric and adolescent T1DM patients, few studies have confirmed these observations in adults. Moreover, data on bone geometry in T1DM remain scarce.Objective: To compare areal and volumetr...

Objective: In type 2 diabetes mellitus, fracture risk is increased despite preserved BMD. This might in part be due to insulin resistance affecting bone geometry; however, studies investigating the associations of insulin sensitivity with bone geometry are lacking. We aimed to explore this relationship in a cohort of healthy, young adult men.Methods: In 1001 healthy men aged 25–45 years, cortical bone geometry was assessed using pQCT (radius and tib...

Sex hormone binding globulin (SHBG) is a plasma glycoprotein responsible for high-affinity binding and transport of sex steroids. In men there is a large interindividual variation of SHBG levels, and consequently of serum total testosterone (T) and serum total estradiol (E2) levels. Family and twin studies suggested a strong genetic contribution to this variation, besides a hormonal and metabolic influence. The aim of this study was to examine the influence of a missense mutat...

Bone metabolism in men is in part determined by sex steroid exposure. This is especially clear during puberty and senescence but it remains to be established whether declines in sex steroid levels during young and middle adulthood associate with changes in bone mass and size. This study investigated changes in bone mineral content (BMC), areal and volumetric bone density (aBMD; vBMD) and bone size in relation to sex steroid levels in 999 young adult men (age 24- 46 years) of w...

Background: Canonical Wnt-signalling is important for bone by regulating osteoblastogenesis and osteoblast function. Bone metabolism is also partly determined by sex steroid exposure and sex differences in serum sclerostin levels have been reported. However, it is unclear whether serum sclerostin and other circulating Wnt-signalling components are sex steroid dependent within healthy men.Objective: To determine whether serum sclerostin, osteoprotegerin (...

Introduction: Although it is well-known that serum testosterone (T) levels decrease in ageing men, to this date no longitudinal data are available on changes in T levels in healthy young adult men.Objective: To investigate age-related longitudinal changes in serum levels of total T, free T and sex hormone binding globulin (SHBG) in healthy young men.Methods: Data from 999 healthy men aged 24–46years who participated in a long...

Background: In elderly men, fracture risk is independently associated with higher serum sex hormone-binding globulin (SHBG) levels1. Previously, we observed lower free estradiol (E2) and higher SHBG levels in a three-generational family study of men with idiopathic osteoporosis2.Objective: To investigate associations between serum SHBG levels and cortical bone size at age of peak bone mass.Design: S...

IntroductionEven in healthy men, androgen levels start decreasing from early adulthood and these decreases are more pronounced in men with an increasing body mass index (BMI). It is, however, unclear to what extent changes in other indices of body composition and metabolic health are associated with changes in sex steroid exposure in healthy men over time.ObjectiveInvestigating longitudinal changes in body co...